Pregabalin in treatment of Diabetic peripheral Neuropathy:
Neuropathic pain is caused by damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body. The pain is usually described as a burning sensation and affected areas are often sensitive to the touch.
Proximal neuropathy is the most painful type of neuropathy.This type of nerve damage is usually only on one side of the body and can affect the hip, buttock, or thigh. Proximal neuropathy can cause severe pain and difficulty with movement, as well as weight and muscle loss.
Pregabalin is used to treat epilepsy and anxiety. It's also taken to treat nerve pain. Nerve pain can be caused by different conditions including diabetes and shingles, or an injury.
Pregabalin capsules and oral solution are also used to relieve neuropathic pain that can occur after a spinal cord injury and to treat fibromyalgia ; a long-lasting condition that may cause pain, muscle stiffness and tenderness, tiredness, and difficulty falling asleep or staying asleep.
Pregalin 75 mg Capsule is a medicine used to relieve pain caused by nerve damage (neuropathic pain) due to diabetes, shingles (herpes zoster infection), spinal cord injury, or other conditions. It is also used to treat widespread muscle pain and stiffness in people with fibromyalgia.
The anticonvulsant Pregabalin is increasingly prescribed for pain, seizures, and psychiatric disorders. Although evidence suggests Pregabalin can cause edema and heart failure, its cardiac safety profile in clinical practice is unknown.
It's fine to take painkillers like paracetamol, ibuprofen and aspirin with Pregabalin, assuming these are appropriate for you. Strong painkillers such as codeine and co-codamol and dihydrocodeine can make you feel more sleepy if taken in combination with Pregabalin.
Pregabalin are good for generalized anxiety
The findings of randomised controlled trials and meta-analyses together indicate that Pregabalin is efficacious in both acute treatment and relapse prevention in GAD(GAD means Generalized Anxiety Disorder), with some evidence of an early onset of effect, and broad efficacy in reducing the severity of psychological and physical symptoms of anxiety.
Pregabalin capsule or oral liquid may be taken with or without food. Take the extended-release tablet after an evening meal. Swallow it whole. Do not crush, break, or chew it.
Pregabalin absorbed is absorbed rapidly .
Pregabalin is rapidly absorbed following oral administration, with peak plasma concentrations occurring between 0.7 and 1.3 hours. Pregabalin oral bioavailability is approximately 90% and is independent of dose and frequency of administration.
Pregabalin has no involvement with serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline re uptake. It has no effects on sodium channels, opiate receptors, and cyclooxygenase enzyme activity.
Side effects of Pregabalin:
Drowsiness, dizziness, headache, dry mouth, nausea, constipation, and weight gain may occur. If any of these effects last or get worse, tell your doctor.
Combination therapy:
Methylcobalamin Pregabalin is a combination of two medicines:
Pregabalin and Methylcobalamin. This combination of two medicines is useful in the treatment of nerve pain (neuropathic pain). It calms the damaged or overactive nerves by acting on the brain, thereby decreasing the pain sensation.Fixed dose combination of sustained-release Pregabalin and Methylcobalamin significantly reduced neuropathic pain, with significant improvement in both the positive and negative symptoms associated with neuropathy, in Indian patients and was well tolerated.
The common side-effects of Methylcobalamin Pregabalin are dizziness, drowsiness, headache, anorexia (loss of appetite), nausea or vomiting, diarrhea, headache, hot sensation (burning pain), vision problems and diaphoresis (sweating). Inform your doctor if any of these side-effects persist.
Pevesca Plus Capsule is used to treat neuropathic pain. It decreases the pain by controlling calcium channel activity and by decreasing the production of a substance that protects nerve fibers and rejuvenates damaged nerve cells.
Pevesca Plus Capsule
Manufactured by USV LTD
Contains Alpha lipoic acid (100 mg) Folic Acid (1.5 mg) Methylcobalamin (750 mcg) Pregabalin (75 mg) Pyridoxine (1.5 mg).
Pevesca Plus Capsule is a combination of Alpha Lipoic Acid, Folic Acid, Methylcobalamin, Pregabalin and Pyridoxine. It is used to treat diabetic neuropathy (a type of nerve damage due to diabetes). This medicine blocks the transfer of pain signals from the damaged nerves. It also helps to repair the damaged nerves. Pevesca Plus Capsule shows side effects like nausea, vomiting, headache, skin rash, indigestion, etc. These side effects usually subside with time as your body adjusts to the medicine. However, consult your doctor if any of these side effects persist or become severe. Avoid driving vehicles or operating machines if you feel dizzy or drowsy after taking this medicine. Pevesca Plus Capsule may be taken with or without food as instructed by your doctor. Take this medicine at the same time every day for the ease of remembering. Avoid the discontinuation of this medicine without consulting your doctor as it may worsen your condition. Pevesca Plus Capsule is not recommended for use if you are allergic to it, or if you have Leber's disease (a rare genetic disorder that occurs due to the death of optic nerve cells in the eyes leading to painless loss of vision). Inform your doctor if you are taking any other medicine, or have any other medical condition before starting the treatment with Pevesca Plus Capsule. Consult your doctor if you are pregnant, planning a pregnancy, or are breastfeeding.
Gabapentin in treatment of Diabetic peripheral Neuropathy:
Gabapentin works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. It is not used for routine pain caused by minor injuries or arthritis.
Gabapentin in Neuropathic pain:
Gabapentin is recommended as a first line treatment for chronic neuropathic pain by various medical authorities. This is a general recommendation applicable to all neuropathic pain syndromes except for trigeminal neuralgia.
In regard to the specific diagnoses, the best evidence exists for gabapentin treatment of postherpetic neuralgia and diabetic neuropathy.Gabapentin is approved for the former indication in the US.In addition to these two neuropathies, European Federation of Neurological Societies guideline notes gabapentin effectiveness for central pain. combination of gabapentin with an opioid or nortriptyline may work better than either drug alone.
Overall, gabapentin shows moderate effectiveness for neuropathic pain. Only a minority of patients obtain meaningful relief. Out of 10 persons treated with gabapentin, three to four benefit substantially as compared to one to two persons treated with placebo.
Evidence finds little or no benefit and significant risk in those with chronic low back pain or sciatica. Gabapentin is not effective in HIV associated sensory neuropathy and neuropathic pain due to cancer. Gabapentin is an anticonvulsant drug. This medicine is available only with your doctor's prescription.
Gabapentin is commonly used to treat some types of nerve pain but is classified as an anticonvulsant medicine, not as an opioid or painkiller.
Gabapentin is used to treat some types of persistent pain. It is especially good for nerve pain, such as burning, shooting or stabbing pain. Gabapentin belongs to the anticonvulsant group of medications, which are also used to treat epilepsy. While you are on this medicine to treat your pain, avoid certain drugs .
Other painkiller to be avoided while taking gabapentin:For example
strong painkillers, such as morphine. These can make you very tired and dizzy when you start taking gabapentin. Avoid antidepressants, such as amitriptyline or fluoxetine. antipsychotic medicines for mental health problems like schizophrenia or bipolar disorder and a medicine to prevent malaria called mefloquine alongwith gabapentin.
The most common side effect of gabapentin:
Gabapentin (Neurontin, Gralise) is a medication used to help manage certain epileptic seizures and relieve pain for some conditions, such as shingles (post therpetic neuralgia). Dizziness and drowsiness are common gabapentin side effects. Weight gain and uncoordinated movement are possible side effects.
Although they're not common side effects, gabapentin has been reported to potentially cause weight gain and fluid buildup in the legs (edema). If you're taking gabapentin or another medication that you think may have led to gaining a few extra pounds, talk to your healthcare provider.
According to researchers, long-term use of gabapentin, a nonopioid pain medication among older adults may cause altered mental status, dizziness, drowsiness and renal dysfunction, and it could also lead to polypharmacy, which in itself can lead to adverse events and hospital stays.
Response and effectiveness: Peak concentrations of gabapentin immediate release occur within 2 to 3 hours. Although gabapentin may improve sleep problems due to nerve pain within a week, it may take up to two weeks for symptom relief from nerve pain to occur.
Gabapentin works in the brain to prevent seizures and relieve pain for certain conditions in the nervous system. It is not used for routine pain caused by minor injuries or arthritis.
Gabapentin is indicated as monotherapy in the treatment of partial seizures with and without secondary generalisation in adults and adolescents aged 12 years and above. Gabapentin is indicated for the treatment of peripheral neuropathic pain such as painful diabetic neuropathy and post-herpetic neuralgia in adults.
Combination therapy:
Gabapentin is also used with other medications to prevent and control seizures. It is also used to relieve nerve pain following shingles (a painful rash due to herpes zoster infection) in adults.
(i)Gabapentin Nortriptyline is a combination of two medicines: Gabapentin and Nortriptyline. This medicine is useful in the treatment of nerve pain (Neuropathic pain). It calms the damaged or overactive nerves by acting on the brain. Thereby, it decreases the pain sensation.
(ii)Gabapentin
Methylcobalamin ,(Gabaneuron) is a combination of two medicines: Gabapentin and Methylcobalamin. This medication is useful in the treatment of pain due to nerve damage (peripheral neuropathy). This medication works by regenerating damaged nerves in the body and decreasing the pain sensation.
Information compiled by: Dr. Bhairavsinh Raol
