Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of Type II diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome in women .It is sometimes used as an off-label adjunct to lessen the risk of metabolic syndrome in people who take antipsychotics. Metformin is not associated with weight gain and is taken by mouth.Metformin is on the WHO List of Essential Medicines, and is the most widely used medication for diabetes taken by mouth.It is available as a generic medication. In 2021,