Diabetic peripheral neuropathy:Part 4 Medicines for the treatment The main medicines recommended for neuropathic pain include:(1)Amitriptyline – also used for treatment of headaches and depression.(2)Duloxetine – also used for treatment of bladder problems and depression.(3)Pregabalin and (4)Gabapentin are also used to treat epilepsy, headaches or anxiety.The treatment for diabetic neuropathy in feet:According to guidelines from the American Academy of Neurology , the most effective medications for treating painful diabetic neuropathy (PDN) include: Pregabalin (Lyrica) Gabapentin (Neurontin) Duloxetine (Cymbalta)This medication is commonly prescribed for neuropathy in diabetic patients and are the three most prescribed medications for neuropathy in diabetic patients.(1) Amitriptyline:This